[Career]
Assistant Professor, Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine (2025.9. - present)
Resident, Department of Preventive Medicine, Seoul National University College of Medicine (2018.3. - 2021.2. )
Intern, Seoul National University Hospital (2017.3. - 2018.2.)
[Education]
PhD, Seoul National University College of Medicine (2020.9. - 2025.8.)
MS, Seoul National University College of Medicine (2018.9. - 2020.8.)
MD, Ajou University School of Medicine (2011.3. - 2017.2.)
주요관심연구
Disease prevention is invaluable, yet the mechanisms underlying disease development remain highly complex and incompletely understood. Our laboratory's mission is to identify novel strategies for disease prevention. We adopt a multidisciplinary approach that integrates epidemiology, genomics, and in-vitro organoid systems to elucidate the pathophysiology of diseases, with a primary focus on-but not limited to-cancer. We aim to address the following fundamental questions (https://sites.google.com/view/sungjimoon).
1. What are the unknown causes of cancer?
Over half of the causes of cancer are known. But the remains have yet to be explored. Under robust epidemiological methodology, we analyze large-scale national health data, such as NHIS, KoGES, or UK-biobank, to find causal associations. In addition, we primarily gather data to investigate the cause of cancer in terms of field epidemiology. We also conduct general or clinical epidemiologic studies, including estimation of the burden of disease, collaboration with clinicians, and development of disease prediction algorithms.
2. How do germline variants and somatic mutations influence disease development and progression?
Despite the discovery of numerous disease-associated variants/mutations, their mechanism affecting phenotype have not been fully understood. We conduct bioinformatic analysis, including GWAS, QTL, single-cell sequencing, and wet-lab experiments, to explore the effect of variants on disease.
3. What are the molecular changes during early oncogenesis?
How normal cells become cancerous is in the dark, where we could find clues for cancer prevention. We explore the cancer evolution mechanism utilizing an in vitro normal organoid model with genetic or non-genetic manipulation.
대표연구업적
1. Novel genetic variants associated with chronic kidney disease progression (Journal of the American Society of Nephrology, 2023)
2. Preventable Cancers Caused by Infection in Korea From 2015 to 2030 (Journal of Korean Medical Science, 2025)
3. Genome-wide association study for metabolic syndrome reveals APOA5 single nucleotide polymorphisms with multilayered effects in Koreans (Lipids in Health and Disease, 2024)
4. Association Between Angiotensin II Receptor Blockers and the Risk of Lung Cancer Among Patients With Hypertension From the Korean National Health Insurance Service-National Health Screening Cohort (Journal of Preventive Medicine and Public Health, 2020)
5. Etiome Study Using Molecular Epigenetic Markers and Lung Organoid in Korean School Meal Service Workers (Etiome Study in S-meal Workers): Study Protocol (Journal of Preventive Medicine and Public Health, 2025)
발전기금
