±³½Ç¼Ò°³

    • home
    • ±³½Ç¼Ò°³
    • ±âÃÊÀÇÇÐ

±âÃÊÀÇÇÐ

  • ÀüÀÓ±³¼ö(ÀÇ°ú´ëÇÐ)
  • ¹èâ´ë
  • ȨÆäÀÌÁö ¹Ù·Î°¡±â http://biomed.skku.edu/biochem
  • Àü°øºÐ¾ß £ü ¹ß¾Ï±âÀü, ¼¼Æ÷ÁÖ±â, ÇÁ·ÎÅ׿À¹Í½º
  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6133 / (fax) 031-299-6149
  • À̸ÞÀÏ     £ü cdbae@skku.edu

ÁÖ¿ä°æ·Â

  • 1987 ¼­¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇÇлç
    1993 ¼­¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇÇйڻç
    1996-1998 Vanderbilt Univ. TN, USA, Research Associate
    1994-1998 ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ÀüÀÓ°­»ç, Á¶±³¼ö
    1999-ÇöÀç ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¶±³¼ö, ºÎ±³¼ö, ±³¼ö.

ÁÖ¿ä°ü½É¿¬±¸

  • Rho small GTP binding proteinÀ» ÅëÇÑ ¼¼Æ÷³» ½ÅÈ£Àü´Þ°úÁ¤.

    Rho family small G proteinÀº Ras superfamily¿¡ ¼ÓÇÏ´Â guanine nucleotide°áÇÕ ´Ü¹éÁú·Î Ras¿Í´Â ´Ù¸¥ »ý¸®ÀÛ¿ëÀ» ¸Å°³ÇÏ´Â ´Ü¹éÁú±ºÀÌ´Ù. À̵éÀº ¼¼Æ÷°ñ°ÝÀÇ º¯È­ ¹× ¼ºÀå, ºÐÈ­µî essential cellular function°ú °ü·ÃµÈ ½ÅÈ£Àü´Þ°è¿¡¼­ ÁÖ¿äÇÑ ¿ªÇÒÀ» ¼öÇàÇÏ°í ÀÖ´Ù. ±×·¯³ª, Rho small G proteinÀÇ È°¼ºÁ¶Àý±âÀüÀº ´Ù¾çÇÑ guanine nucleotide exchange factor(GEF)¸¦ ºñ·ÔÇÑ º¹ÀâÇÑ regulator·Î ÀÎÇÏ¿© Á¤È®ÇÑ ºÐÀÚ¼öÁØÀÇ ±âÀüÀÌ ±Ô¸íµÇÁö ¾Ê°í ÀÖÀ¸¸ç, ¶ÇÇÑ, overlay assay³ª yeast two hybrid ¹æ¹ýÀ» ÀÌ¿ëÇÏ¿© Rho small G protein¿¡ °áÇÕÇÏ´Â °ÍÀ¸·Î ¹àÇôÁø effectorµéÀÌ °¢ Rho ´Ü¹éÁú°ú ¼¼Æ÷³»¿¡¼­ °áÇÕÇϴ ƯÀ̼ºÀÌ ³·¾Æ¼­ ¾î¶² downstream effector¸¦ ÅëÇÏ¿© °¢ Rho´Ü¹éÁú¿¡ ƯÀÌÇÑ ±â´ÉÀÌ ¼öÇàµÇ´ÂÁö ¸ðÈ£ÇÑ »óÅÂÀÌ´Ù. µû¶ó¼­, Rho family small G proteinÀ» ÅëÇÑ ¼¼Æ÷³» ½ÅÈ£Àü´Þ°úÁ¤À» ¸íÈ®È÷ Çϱâ À§Çؼ­´Â ¸ÕÀú, °¢ Rho ´Ü¹éÁú¿¡ ƯÀÌÇÏ°Ô ÀÛ¿ëÇÏ´Â regulator¹× effector¸¦ ã°Å³ª, ºÐ·ùÇÏ´Â °úÁ¤ÀÌ ¼±ÇàµÇ¾î¾ß ÇÒ °ÍÀÌ´Ù. À̸¦ À§ÇÏ¿© º» ½ÇÇè½Ç¿¡¼­´Â, 1) chimeric Rhoprotein¹× point mutant Rho proteinÀ» ÀÌ¿ëÇÏ¿© Rho family small G proteinÀ» ÅëÇÑ ½ÅÈ£Àü´ÞÀÇ Æ¯À̼ºÀ» ºÐ·ùÇÏ´Â ¿¬±¸¸¦ ¼öÇàÁßÀ̸ç, 2) ±Ø½ÉÇÑ ¼¼Æ÷¸ð¾çÀÇ º¯È­¸¦ ÃÊ·¡ÇÏ´Â ½Å°æ¼¼Æ÷ÀÇ ºÐÈ­°úÁ¤¿¡ ¼ö¹ÝµÇ´Â Rho family small G proteinÀÇ È°¼ºº¯È­¸¦ À¯¹ßÇϴµ¥ °ü¿©ÇÏ´Â GEF¸¦ ºñ·ÔÇÑ regulator¹× È°¼ºÈ­µÈ Rho´Ü¹éÁúÀÇ downstream effect¿¡ ´ëÇÑ ºÐÀÚ¼öÁØÀÇ ±âÀüÀ» ¿¬±¸ÇÏ°í ÀÖ´Ù.


´ëÇ¥¿¬±¸¾÷Àû

  • 1) Park K-H, Lee J-R, Hahn H-S, Kim Y-H, Bae CD, Yang J-M, Oh ST, Bae Y-J, Kim D-E, Hahn M-J. Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism. Chem. Pharm. Bull. 54(9) 1266-1270. 2006.

    2) Sang-MIn Jeon, Bongkun Choi, Kyung Uk Hong, Eunhee Kim, Yeon-Sun Seong, Chang-Dae Bae, Joobae Park. A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts. BBRC. 348 (2006) 222-228.

    3) Soon Youn Jeong, Sun Young Shin, Han-Seop Kim, Chang-Dae Bae, Dae-Yong Uhm, Myung-Kyu Park, Sungkwon Chung. Regulation of magnesium-inhibited cation current by actin cytoskeleton rearrangement. BBRC. 339 (2006) 810-815.