2005.03 - 2009.02 POSTECH 생명과학과, 학사
2009.03 - 2017.02 서울대학교 생명과학부, 박사
2017.03 - 2018.02 서울대학교 기초과학연구원, 박사후연구원
2018.03 - 2022.01 St. Jude Children's Research Hospital, 박사후연구원
2022.02 - 현재 성균관대학교 의과대학 분자세포생물학교실, 조교수/부교수
주요관심연구
Our laboratory investigates the principles that govern the formation, material properties, and biological functions of biomolecular condensates in cells. We study how phase separation organizes intracellular environments and regulates processes such as gene expression, RNA metabolism, and cellular stress responses through dynamic assemblies including paraspeckles, stress granules, and other RNA?protein condensates.
By integrating advanced live-cell imaging, quantitative image analysis, molecular and cell biology, and multi-omics approaches, we aim to understand how the biophysical properties of condensates influence cellular function and homeostasis.
We are also interested in how condensates can transition from liquid-like states to more solid-like assemblies, a process that can initiate protein aggregation during cellular stress or aging. Understanding these phase transitions is particularly important because aberrant condensate maturation is increasingly linked to neurodegenerative diseases, where dynamic RNA?protein assemblies can convert into pathological aggregates.
Ultimately, our goal is to uncover fundamental mechanisms connecting condensate biophysics with cellular function, aging, and disease.
대표연구업적
1. Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics. Gemone Biology. 2025 Sep. 26(1):264.
2. Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence. Redox Biology 2024 Sep. 75:103279.
3. Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Science. 2021 Jun 372(6549):eabf6548.
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