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  • ÀüÀÓ±³¼ö(ÀÇ°ú´ëÇÐ)
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  • ȨÆäÀÌÁö ¹Ù·Î°¡±â http://biomed.skku.edu/schung
  • Àü°øºÐ¾ß £ü ½Å°æ»ý¸®ÇÐ
  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6103 / (fax) 031-299-6129
  • À̸ÞÀÏ     £ü schung@skku.edu

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  • 1979 - 1983 ¼­¿ï´ëÇб³ ÀÚ¿¬°úÇдëÇÐ È­Çаú ÀÌÇлç (B.S.)
    1983 - 1985 ¼­¿ï´ëÇб³ ´ëÇпø È­Çаú »ýÈ­ÇÐÀü°ø ÀÌÇм®»ç (M.S.)
    1986 - 1991 Brandeis University, Waltham, Massachusetts, U.S.A. (Ph.D.)
    1992 - 1994 Postdoctoral Associate, Yale Medical School
    1994 - 1996 ¾Æ»ê »ý¸í°úÇבּ¸¼Ò ¼±ÀÓ¿¬±¸¿ø
    1996 - 1999 Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇб³ Á¶±³¼ö
    1999 - ÇöÀç ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇб³ Á¶±³¼ö, ºÎ±³¼ö, ±³¼ö

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  • ¾ËÃ÷ÇÏÀ̸Ӻ´Àº ´ëÇ¥ÀûÀÎ ÅðÇ༺ ³úÁúȯ (neuro-degenerative disease)À¸·Î ÇÁ·¹¼¼´Ò¸° (presenilin) ´Ü¹éÁúÀÇ º¯ÀÌ¿¡ ÀÇÇÑ º£Å¸¾Æ¹Ð·ÎÀ̵å (A¥â42)ÀÇ ºÐºñ Áõ°¡°¡ °¡Àå Àß ¾Ë·ÁÁø º´¸®±âÀüÀÌ´Ù. º» ¿¬±¸ÆÀÀº ÇÁ·¹¼¼´Ò¸°ÀÇ º¯ÀÌ¿¡ ÀÇÇØ ¼¼Æ÷ ³» Ä®½·½ÅÈ£ÀÇ º¯È­°¡ ¹ß»ýÇÔÀ» óÀ½À¸·Î º¸°íÇÏ¿´´Ù (Yoo et al., Neuron, 2000). ÃÖ±ÙÀÇ ¿¬±¸¸¦ ÅëÇؼ­ ÇÁ·¹¼¼´Ò¸°ÀÇ º¯ÀÌ¿¡ ÀÇÇÑ Ä®½·½ÅÈ£ÀÇ º¯È­´Â Ä®½·À¯ÀÔ Åë·ÎÀÇ ÇÑ Á¾·ùÀÎ TRPM7 ÀÌ¿ÂÅë·ÎÀÇ È°¼º°¨¼Ò¿¡ ÀÇÇÑ °ÍÀÓÀ» È®ÀÎÇÏ¿´À¸¸ç, ±× ºÐÀÚ±âÀüÀ¸·Î¼­ ¼¼Æ÷¸·ÀÇ Áß¿äÇÑ ½ÅÈ£Àü´Þ¹°ÁúÀÎ PIP2ÀÇ ³óµµ°¨¼Ò¸¦ È®ÀÎÇÏ¿´´Ù (Landman et al., PNAS, 2006). A¥â42ÀÇ ºÐºñÁõ°¡ ±âÀü ¿ª½Ã PIP2ÀÇ ³óµµ°¨¼Ò ¶§¹®ÀÎ °ÍÀ¸·Î ½ÇÇè°á°ú È®ÀεǾú±â ¶§¹®¿¡ ÇÁ·¹¼¼´Ò¸° º¯ÀÌ¿¡ ÀÇÇØ ³ªÅ¸³ª´Â Çö»óÀÎ A¥â42ÀÇ ºÐºñ Áõ°¡¿Í ¼¼Æ÷³» Ä®½·½ÅÈ£ º¯È­ ¸ðµÎ µ¿ÀÏÇÑ ±âÀü¿¡ ÀÇÇØ ¹ß»ýµÇ°í ÀÖÀ½À» ¾Ë ¼ö ÀÖ¾ú´Ù. ¿¬±¸½Ç¿¡¼­ ¾ò¾îÁø ÀÌ°°Àº ÃÖ±ÙÀÇ °á°úµéÀ» ¹ÙÅÁÀ¸·Î ¾ËÃ÷ÇÏÀ̸Ӻ´ÀÇ »õ·Î¿î Ä¡·áÁ¦ÀÇ Å¸±êÀ» ã°í, ¾à¹°À» ½ºÅ©¸°ÇÏ´Â ¿¬±¸¸¦ ¼öÇàÇÏ°í ÀÖ´Ù.

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  • 1) Yoo AS, Cheng I, Chung S et al. (2000) Presenilin-mediated modulation of capacitative calcium entry. Neuron 27:561-572.

    2) Landman N, Serban G, Shin SY, Kang MS, Chung S*, Kim T-W* (2006) An essential role for phosphatidylinositol-4,5-bisphosphate in familial Alzheimer''s disease-linked presenilin mutations. PNAS 103:19524-19529. * co-corresponding authors.

    3) Kang et al. (2013) Modulation of lipid kinase PI4KIIa activity and lipid raft association of presenilin 1 underlies g-secretase inhibition by ginsenoside. J. Biol. Chem., 288:20868.

    4) Chun et al. (2015) O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-b protein precursor via inhibition of endocytosis from the plasma membrane. J. Alzheimer¡¯s Disease 44:261.