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  • ȨÆäÀÌÁö ¹Ù·Î°¡±â https://ilminkwon.wixsite.com/kwonlab
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  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6075 / (fax)
  • À̸ÞÀÏ     £ü ilmin.kwon@skku.edu

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  • 1996 ~ 2003 ÇѾç´ëÇб³ »ý¸í°úÇаú (Çлç)
    2003 ~ 2005 ¼­¿ï´ëÇб³ »ý¸í°úÇкΠ(¼®»ç)
    2005 ~ 2009 ¼­¿ï´ëÇб³ »ý¸í°úÇкΠ(¹Ú»ç)
    2009 ~ 2010 ¼­¿ï´ëÇб³ »ý¸í°úÇкΠ(¹Ú»çÈÄ ¿¬±¸¿ø)
    2010 ~ 2015 University of Texas Southwestern Medical Center (¹Ú»çÈÄ ¿¬±¸¿ø)
    2015 ~ ÇöÀç ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ (ºÎ±³¼ö)

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  • 1. ¼¼Æ÷ ³»¿¡¼­ Áß¿äÇÑ ¿ªÇÒÀ» ¼öÇàÇÏ´Â ´Ù¾çÇÑ ´Ü¹éÁúµé¿¡ ÀÇÇÑ ¡®»ó ºÐ¸®(phase separation)¡¯ Çö»óÀÇ ºÐÀÚ±âÀü ±Ô¸í ¹× À̸¦ ÅëÇÑ ¼¼Æ÷ ³» ´Ü¹éÁú ±â´É Á¶Àý ¿¬±¸.

    2. C9orf72 À¯ÀüÀÚ º¯ÀÌ¿¡ ÀÇÇÑ ·ç°Ô¸¯º´(ALS, amyotrophic lateral sclerosis)ÀÇ ¹ßº´±âÀü°ú Ä¡·á¹ý ¿¬±¸.

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  • Lee J, Cho H* and Kwon I* (2022) Phase separation of low-complexity domains in cellular function and disease. Exp. Mol. Med. 54:1-11 (Review article, *Co-corresponding authors)

    Jo Y*, Lee J*, Lee S*, Kwon I and Cho H (2022) Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause ive motor neuron hyperexcitability in ALS. Proc. Natl. Acad. Sci. 119 (11) e2113813119. (*Co-first authors Co-corresponding authors)

    Kim GH and Kwon I (2021) Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription. Proc. Natl. Acad. Sci. 118 (50) e2109668118.

    Kim E and Kwon I (2021) Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin. Biochem. J. 478 (4):799-810.

    Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I*, and McKnight SL* (2016) Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target LC domain polymers. Cell. 167:789-802. (*Co-corresponding authors)

    Kwon I, Xiang S, Kato M, Wu L, Theodoropoulos P, Wang T, Kim J, Yun J, Xie Y, and McKnight SL (2014) Poly-dipeptides encoded by the C9ORF72 repeats bind nucleoli, impede RNA biogenesis, and kill cells. Science. 345:1139-45.

    Kwon I*, Kato M*, Xiang S, Wu L, Theodoropoulos P, Mirzaei H, Han T, Xie S, Corden JL, and McKnight SL (2013) Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains. Cell. 155:1049-60. (*Co-first authors)