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기초의학

목록
  • 전임교수(의과대학)
  • 강동묵
  • 홈페이지 바로가기 http://biomed.skku.edu/ionchannel
  • 전공분야 ｜ 전기생리학, 이온채널, 근육생리학
  • 연락처     ｜ (전화) 031-299-6102 / (fax) 031-299-6129
  • 이메일     ｜ tongmkang@skku.edu

주요경력

  • 학력
    1988. 2: 서울대학교 수의과대학, 수의학사
    1994. 8: 서울대학교 대학원, 수의학박사 (생리학)

    경력
    1994 - 1995: 단국대학교 의과대학, 조교
    1995 - 1998: 삼성생명과학연구소, 연구원
    1998 - 현재: 성균관대학교 의과대학 생리학교실, 전임강사/조교수/부교수/교수
    2001 - 2003: Visiting Assistant Professor, Department of Physiology, University of Texas Southwestern Medical Center at Dallas, USA
    2006 - 2024: 한국이온통로연구회, 총무
    2006 - 2008: 대한생리학회, 기획간사
    2008 - 2010: 대한생리학회, 감사
    2008 - 2020: 대한생리학회, 학술위원
    2010 - 현재: 대한생리학회, 이사
    2011 - 2013: 부편집위원장(Associate Editor), Korean Journal of Physiology & Pharmacology
    2013 - 2023: 대한생리학회, 간행이사
    2013 - 2023: 편집위원장(Editor-in-Chief), Korean Journal of Physiology & Pharmacology
    2016 - 2017: 편집위원장(Editor-in-Chief), Precision and Future Medicine
    2017 - 현재: 편집위원(Editorial Board Member), Pflugers Archiv-European Journal of Physiology
    2020 - 2023: 대한의학학술지편집인협의회(KAMJE), 평가위원회 간사

주요관심연구

  • - 이온채널 및 세포칼슘신호(Ion channels & intracellular calcium signaling)
    - 이온채널질환(Channelopathies): 부정맥(arrhythmias), 요실금(OAB/UI), 난청(hearing loss)
    - 이온채널 신약개발 및 hERG 심장독성평가(Ion channel drug discovery & hERG assay)
    - 근육생리학(Muscle Physiology): 심장근(heart), 평활근(smooth muscles), 골격근(skeletal muscles)
    - 인공근육 개발(Development of artificial muscles)

대표연구업적

  • 1. Comprehensive genetic profiling of sensorineural hearing loss using an integrative diagnostic approach. Cell Rep Med (2025) 6(7):102206.
    2. Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss. Exp Mol Med (2021) 53(7):1192-1204.
    3. Biomimetic cell-actuated artificial muscle with nanofibrous bundles. Microsyst Nanoeng (2021) 7:70.
    4. Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane. Korean J Physiol Pharmacol (2020) 24(6):529-543.
    5. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep (2018) 8:16659.
    6. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep (2017) 7:40872.
    7. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J Cell Biol (2017) 216(7):2091-2105.
    8. Bio-inspired hybrid carbon nanotube muscles. Sci Rep (2016) 6:26687.
    9. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun (2013) 430(2):722-8.
    10. Enhanced actuation of PPy/CNT hybrid fibers using porous structured DNA hydrogel. Sensors and Actuators B (2010) 145:89-92.
    11. Tough supersoft sponge fibers with tunable stiffness from a DNA self-assembly technique. Angew Chem Int Ed Engl (2009) 48(28):5116-20.
    12. Switchable redox activity by proton fuelled DNA nano-machines. Chem Commun (Camb) (2009) 14(10):1240-2.
    13. Fullerene attachment enhances performance of a DNA nanomachine. Adv. Mater. (2009) 21:1-4.
    14. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism (2008) 8(4)318-324.
    15. DNA-Wrapped single-walled carbon nanotube hybrid fibers for supercapacitors and artificial muscles. Adv. Mater. (2008) 20:466-470.
    16. DNA hydrogel fiber with self-entanglement prepared by using an ionic liquid. Angew Chem Int Ed Engl (2008) 47(13):2470-4.
    17. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature (2004) 427(6974):544-548.
    18. Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes. J Gen Physiol (2003) 121:325-347.
    19. The properties of carbachol-activated nonselective cation channels at the single channel level in guinea pig gastric myocytes. Jpn J Pharmacol (2001) 85(3):291-8.