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±âÃÊÀÇÇÐ

  • ÀüÀÓ±³¼ö(ÀÇ°ú´ëÇÐ)
  • °­µ¿¹¬
  • ȨÆäÀÌÁö ¹Ù·Î°¡±â http://biomed.skku.edu/ionchannel
  • Àü°øºÐ¾ß £ü Àü±â»ý¸®ÇÐ, ÀÌ¿Âä³Î, ±ÙÀ°»ý¸®ÇÐ
  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6102 / (fax) 031-299-6129
  • À̸ÞÀÏ     £ü tongmkang@skku.edu

ÁÖ¿ä°æ·Â

  • ÇзÂ
    1988. 2: ¼­¿ï´ëÇб³ ¼öÀÇ°ú´ëÇÐ, ¼öÀÇÇлç
    1994. 8: ¼­¿ï´ëÇб³ ´ëÇпø, ¼öÀÇÇйڻç (»ý¸®ÇÐ)

    °æ·Â
    1994 – 1995: ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ, Á¶±³
    1995 – 1998: »ï¼º»ý¸í°úÇבּ¸¼Ò, ¿¬±¸¿ø
    1998 – ÇöÀç: ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ »ý¸®Çб³½Ç, ÀüÀÓ°­»ç/Á¶±³¼ö/ºÎ±³¼ö/±³¼ö
    2001 – 2003: Visiting Assistant Professor, Department of Physiology, University of Texas Southwestern Medical Center at Dallas, USA
    2006 – ÇöÀç: Çѱ¹ÀÌ¿ÂÅë·Î¿¬±¸È¸, Ãѹ«
    2006 – 2008: ´ëÇÑ»ý¸®ÇÐȸ, ±âȹ°£»ç
    2008 – 2010: ´ëÇÑ»ý¸®ÇÐȸ, °¨»ç
    2008 – ÇöÀç: ´ëÇÑ»ý¸®ÇÐȸ, ÇмúÀ§¿ø
    2010 – ÇöÀç: ´ëÇÑ»ý¸®ÇÐȸ, ÀÌ»ç
    2013 – ÇöÀç: ´ëÇÑ»ý¸®ÇÐȸ, °£ÇàÀÌ»ç
    2011 – 2013: ºÎÆíÁýÀ§¿øÀå(Associate Editor), Korean Journal of Physiology & Pharmacology
    2013 – ÇöÀç: ÆíÁýÀ§¿øÀå(Editor-in-Chief), Korean Journal of Physiology & Pharmacology
    2016 – 2017: ÆíÁýÀ§¿øÀå(Editor-in-Chief), Precision and Future Medicine
    2017 – ÇöÀç: ÆíÁýÀ§¿ø(Editorial board), Pflügers Archiv-European Journal of Physiology

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  • ¿¬±¸ºÐ¾ß
    - ÀÌ¿Âä³Î ¹× ¼¼Æ÷Ä®½·½ÅÈ£(Ion channels & intracellular calcium signaling)
    - ÀÌ¿Âä³ÎÁúȯ(Channelopathies): ºÎÁ¤¸Æ(arrhythmias), ¿ä½Ç±Ý(OAB/UI), ³­Ã»(hearing loss)
    - ÀÌ¿Âä³Î ½Å¾à°³¹ß ¹× hERG ½ÉÀ嵶¼ºÆò°¡(Ion channel drug discovery & hERG assay)
    - ±ÙÀ°»ý¸®ÇÐ(Muscle Physiology): ½ÉÀå±Ù(heart), ÆòÈ°±Ù(smooth muscles), °ñ°Ý±Ù(skeletal muscles)
    - Àΰø±ÙÀ° °³¹ß(Development of artificial muscles)

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  • ´ëÇ¥³í¹®
    1. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Biomaterials. (2018) 193:30-46.

    2. Discovery of natural compounds promoting cardiomyocyte differentiation. Stem Cells and Development. 2018 Oct 25. doi: 10.1089/scd.2018.0153.

    3. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep. (2018) 8:16659.

    4. Biomolecule based fiber supercapacitor for implantable device. Nano Energy (2018) 47:385-392.

    5. mTOR controls ChREBP transcriptional activity and pancreatic ¥â cell survival under diabetic stress. J Cell Biol. (2017) 216(7):2091-2105.

    6. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep. (2017) 7:40872.

    7. Bio-inspired hybrid carbon nanotube muscles. Sci Rep. (2016) 6:26687.

    8. TrpA1 regulates defecation of food-borne pathogens under the control of the duox pathway. PLoS Genet. (2016) 12(1):e1005773.

    9. Visceral hypersensitivity and altered colonic motility in type 2 diabetic rat. J Neurogastroenterol Motil. (2015) 21(4):581-8.

    10. Development of cell-based assay system that utilizes a hyperactive channel mutant for high-throughput screening of BK(Ca) channel modulators. J Biotechnol. (2013) 167(1):41-6.

    11. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. Cancer Res. (2013) 73(3):1056-62.

    12. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. (2013) 430(2):722-8.

    13. Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1. Mol Biol Cell. (2012) 23(7):1376-87.

    14. Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells. Pflugers Arch. (2012) 463(2):309-18.

    15. CD40 co-stimulation inhibits sustained BCR-induced Ca signaling in response to long-term antigenic stimulation of immature B cells. Korean J Physiol Pharmacol. (2011) 15(3):179-87.

    16. Improved quantification of islet transplants by magnetic resonance imaging with Resovist. Pancreas (2011) 40(6):911-9.

    17. Kir3.1 channel is functionally involved in TLR4-mediated signaling. Biochem Biophys Res Commun. (2011) 407(4):687-91.

    18. TNF-alpha inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cells. Biochem Biophys Res Commun. (2010) 391(1):909-14.

    19. Enhanced actuation of PPy/CNT hybrid fibers using porous structured DNA hydrogel. Sensors and Actuators B (2010) 145:89-92.

    20. Tough supersoft sponge fibers with tunable stiffness from a DNA self-assembly technique. Angew Chem Int Ed Engl. (2009) 48(28):5116-20.

    21. Switchable redox activity by proton fuelled DNA nano-machines. Chem Commun (Camb). (2009) 14(10):1240-2.

    22. Fullerene attachment enhances performance of a DNA nanomachine. Adv. Mater. (2009) 21:1-4.

    23. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism (2008) 8(4)318-324.

    24. DNA-Wrapped single-walled carbon nanotube hybrid fibers for supercapacitors and artificial muscles. Adv. Mater. (2008) 20:466-470.

    25. PKC-Independent Stimulation of Cardiac Na/Ca Exchanger by Staurosporine. Korean J Physiol Pharmacol. (2008) 12(5):259-65.

    26. TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands. Biochem Biophys Res Commun. (2008) 370(2):295-300.

    27. DNA hydrogel fiber with self-entanglement prepared by using an ionic liquid. Angew Chem Int Ed Engl. (2008) 47(13):2470-4.

    28. Arachidonic acid-induced activation of large-conductance potassium channels and membrane hyperpolarization in mouse B cells. Pflugers Arch. (2008) 456(5):867-81.

    29. Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats. World J Gastroenterol. (2008) 14(5):731-6.

    30. Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes. Pflugers Arch. (2008) 456(3):549-60.

    31. Mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes. J Physiol. (2007) 582(Pt 3):977-90.

    32. Actin cytoskeletons regulate the stretch-induced increase of Ca2+ current in human gastric myocytes. Biochem Biophys Res Commun. (2007) 352(2):503-8.

    33. Voltage-dependent slowly activating anion current regulated by temperature and extracellular pH in mouse B cells. Pflugers Arch. (2006) 452(6):707-17.

    34. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Peptides (2006) 27(5):997-1004.

    35. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature (2004) 427(6974):544-548.

    36. Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes. J Gen Physiol (2003) 121:325-347.

    37. The properties of carbachol-activated nonselective cation channels at the single channel level in guinea pig gastric myocytes. Jpn J Pharmacol. (2001) 85(3):291-8.

    38. Caffeine- and histamine-induced oscillations of K(Ca) current in single smooth muscle cells of rabbit cerebral artery. Pflugers Arch. (1995) 431(1):91-100.