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기초의학

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  • 전임교수(의과대학)
  • 백관혁
  • 전공분야 ｜ 종양생물학
  • 연락처     ｜ (전화) 031-299-6162 / (fax)
  • 이메일     ｜ khbaek@skku.edu

주요경력

  • 3/1990 ~ 2/1994. B.Sc., Life Science, Pohang University of Science and Technology, Korea.
    3/1994 ~ 2/1997. M.Sc., Viral Immunology, Pohang University of Science and Technology, Korea.
    3/1997 ~ 2/2002. Ph.D., Cellular Immunology, Pohang University of Science and Technology, Korea.
    3/2002 ~ 6/2003. Postdoctoral fellow, Pohang University of Science and Technology, korea.
    7/2003 ~ 12/2005. Postdoctoral fellow, Research Institute, National Cancer Center, Korea.
    1/2006 ~ 4/2006. Postdoctoral fellow, SamSung Biomedical Research Institute,Sungkyunkwan University School of Medicine, Korea.
    5/2006 ~ 6/2009. Research fellow, Vascular Biology Program, Department of Surgery, Children’s Hospital, Boston, Harvard Medical School.
    6/2009 ~ 2/2010. Postdoctoral Fellow, Dept. of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine.
    3/2010 ~ present. Assistant professor, Dept. of Molecular and Cellular Biology, Sungkyunkwan University School of Medicine

주요관심연구

  • 1) The role of Down Syndrome Critical Region-1 (DSCR-1), an endogenous calcineurin inhibitor, in reduced tumor incidience of Down Syndrome indivisuals.
    - It has been reported that the incidience of solid tumors is significantly decreased more than 10 fold in Down Syndrome individuals compared with that of normal individuals. To demonstrate which genes on chromosome 21 contribute to the suppression of tumor development in Down Syndrome individuals and what is the underlying mechanism of their functions, we are addressing the influence of their overexpression on oncogene-mediated tumorigenesis using conditional knock-in mice for oncogenic K-ras and Down Syndrome model mice.

    2) The role of genomic instability in oncogene-mediated tumorigenesis.
    -It has been suggested that genomic instability during tumorigenesis shows positive correlation with tumor malignancy and poor prognisis. However, recently, it was also reported that the induction of genomic instability leads to the cellular senescence, a permanant cell growth arrest which functions as a first defence-line for tumor development. For these reasons, the role of genomic instability during tumor development in vivo is still controversal. To make clear the role of genomic instability in tumorigenesis, our lab is investigating the progression of tumors triggered by oncogene expression in mice models with genomic instability.

대표연구업적

  • 1. Lee EH, Kim SS, Lee S, Baek KH, Seo SR. Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation. J Biol Chem. 2015. 290(34):21019-31.

    2. Leem YE, Ha HL, Bae JH, Baek KH and Kang JS. CDO, an Hh-Coreceptor, Mediates Lung Cancer Cell Proliferation and Tumorigenicity through Hedgehog Signaling. PLoS One. 2014. 9(11):e111701.

    3. Schadler KL, Crosby EJ, Zhou AY, Bhang DH, Braunstein L, Baek KH, Crawford D, Crawford A, Angelosanto J, Wherry E and Ryeom S. Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. Cancer Res. 2014. 74(8):2171-81.

    4. Kim SY*, Baik KH*, Baek KH*, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E and Lee KY. S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol. 2014. 34(3):510-21.
    * These authors contributed equally to this work.

    5. Ki CS, Jung CL, Kim HJ, Baek KH, Park SJ, On YK, Kim KS, Noh SJ, Youm JB, Kim JS and Cho H. A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation. Pflugers Arch. 2014. 466(3):529-40.

    6. Shin J, Lee JC and Baek KH. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014. 342(1):70-81.

    7. Lee JC, Shin J and Baek KH. Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras. Biochem. Biophys. Res. Commun. 2013. 440(1):50-55.

    8. Shin J, Yang J, Lee JC and Baek KH. Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence. Cell. Signal. 2013. 25(12).2540-2547.

    9. Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E and Lee KY. Salt-Inducible Kinases 1 and 3 Negatively Regulate Toll-Like Receptor 4-Mediated Signal. Mol. Endocrinol. 2013. 27(11):1958-1968.

    10. Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI and Ryeom S. Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors. J. Clin. Invest. 2013. 123(10): 4375-4389.

    11. Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, and Ryeom S. The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood. 2013. 121(16):3205-3215.

    12. Kim HS, Baek KH, Ha GH, Lee JC, Kim YN, Lee J, Park HY, Lee NR, Lee H, Cho Y, Lee CW. The hsSsu72 phosphatase is a cohesion-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO J. 2010. 29(20):3544-3557.

    13. Zaslavsky A, Chen C, Grillo J, Baek KH, Holmgren L, Yoon S, Folkman J, and Ryeom S. Regional Control of Tumor Growth. Mol. Cancer Res. 2010. 8(9):1198-1206.

    14. Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE, and Ryeom S. Platelet-derived thrombospondin-1 (TSP-1) is a critical negative regulator and potential biomarker of angiogenesis. Blood. 2010. 115(22):4605-4613.

    15. Ryeom S, Baek KH, and Zaslavsky A. Down''s syndrome: protection against cancer and the therapeutic potential of DSCR1. Future Oncol. 2009. 5(8):1185-1188.

    16. Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. Int. J. Radiat. Oncol. Biol. Phys. 2009. 74(4):1207-1216.

    17. Baek KH*, Zaslavsky A*, Lynch R*, Britt C, Okada Y, Siarey R, Lensch W, Park IH, Yoon S, Minami T, Reeves R, Korenberg J, Folkman J, Daley G, Aird W, Galdzicki Z, and Ryeom S. Down’s syndrome suppression of tumor growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009. 459(7250):1126-1130.
    * These authors contributed equally to this work.

    18. Ryeom S, Baek KH, Rioth M, Lynch R, Zaslavsky A, Birsner A, Yoon S, and McKeon F. Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth. Cancer Cell. 2008. 13(5):420-431.

    19. Foo S, Ma Y, Ruas J, Bommi-Reddy A, Girnun J, Cooper M, Laznik D, Rosenzweig A, Spiegelman B, Chinsomboon J, Baek KH, and Arany Z. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1. Nature. 2008. 451(7181):1008-1012.
    20. Ha GH, Baek KH, Kim HS, Jeong SJ, McKeon F, and Lee CW. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Res. 2007. 67(15):7155-7154.

    21. Baek KH, Park HY, Kang CM, Kim SJ, Jeong SJ, Hong EK, Park JW, Sung YC, Suzuki T, Kim CM, and Lee CW. Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation. J Mol. Biol. 2006. 359(1):22-34.

    22. Baek KH*, Shin HJ*, Jeong SJ, Park JW, McKeon F, Lee CW, Kim CM. Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor. Oncol Res. 2005. 15(3):161-168.
    * These authors contributed equally to this work.

    23. Jeong SJ, Shin HJ, Kim SJ, Ha GH, Cho BI, Baek KH, Kim CM, and Lee CW. Transcriptional abnormality of the hsMAD2 mitotic checkpoint gene is a potential link to hepatocellular carcinogenesis. Cancer Res. 2004. 64(23):8666-8673.

    24. Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, and Lee CW. WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase. FEBS Lett. 2004. 575(1-3):23-29.

    25. Ha SJ, Kim DJ, Baek KH, Yun YD, and Sung YC. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol. 2004. 172(1):525-531.

    26. Shin HJ*, Baek KH*, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, and Lee CW. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell. 2003. 4(6):483-497.
    * These authors contributed equally to this work.

    27. Kim BM, Lee DS, Choi JH, Kim CY, Son M, Suh YS, Baek KH, Park KS, Sung YC, and Kim WB. (2003). In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice. Arch Pharm Res. 2003. 26(6):493-498.

    28. Shin HJ, Baek KH, Jeon AH, Kim SJ, Jang KL, Sung YC, Kim CM, and Lee CW. Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. Oncogene. 2003. 22(25): 3853-3858.

    29. Baek KH, Shin HJ, Yoo JK, Cho JH, Choi YH, Sung YC, McKeon F, and Lee CW. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol. 2003. 73(6):850-861.

    30. Baek KH, Ha SJ, and Sung YC. A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages. J Immunol. 2001. 167(5):2847-2854.

    31. Lee SW, Song MK, Baek KH, Park Y, Kim JK, Lee CH, Cheong HK, Cheong C, and Sung YC. Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J Immunol. 2000. 165(7):3631-3639.