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  • Àü°øºÐ¾ß £ü ºÐÀڽŰæ»ý¸®ÇÐ
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  • À̸ÞÀÏ     £ü kimhyunjin@skku.edu

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  • 1994.3-2000.2 ¼­¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇÇлç
    2000.3-2001.2 ¼­¿ï´ëÇб³ º´¿ø ÀÎÅÏ
    2001.3-2006.2 ¼­¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇÇйڻç (»ý¸®ÇÐ)
    2006.3-2010.1 ¹Ì±¹ University of Texas Southwestern Medical Center at Dallas, Post-doc Researcher
    2010.3- ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¶±³¼ö/ºÎ±³¼ö/±³¼ö

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  • 1) ÀÌ¿ÂÅë·Î(ion channel)ÀÇ ±â´É ¿¬±¸
    ÀÌ¿ÂÅë·Î´Â À¯ÀüüÀÇ 1.3%¿¡ ºÒ°úÇÏÁö¸¸ ½Å°æ¼¼Æ÷ÀÇ Àü±â½ÅÈ£ »ý¼º, ±ÙÀ°ÀÇ ¼öÃà, È£¸£¸ó ºÐºñ µî ¼¼Æ÷ÀÇ Áß¿äÇÑ »ý¸®±â´ÉÀ» ´ã´çÇÑ´Ù. ƯÁ¤ ÀÌ¿ÂÅë·ÎÀÇ È°¼ºÀ» Á¶ÀýÇÏ¸é °ü·ÃÇÑ ¼¼Æ÷»ý¸®Çö»óÀ» Á¦¾îÇÏ´Â °ÍÀÌ °¡´ÉÇϱ⿡, ÀÌ¿ÂÅë·Î´Â ¾à¹°°³¹ßÀÇ ÁÖ¿ä Ÿ°ÙÀÌ µÇ¾î¿Ô´Ù. °íÇ÷¾Ð, °íÁöÇ÷Áõ, ºÒ¸éÁõ, °£Áú µîÀÇ Ä¡·áÁ¦°¡ ÀÌ¿ÂÅë·Î¸¦ Ÿ°ÙÀ¸·Î ÇÏ´Â ´ëÇ¥ÀûÀÎ ¾à¹°µéÀ̸ç, ÇöÀç ÀÌ¿ÂÅë·ÎŸ°Ù Ä¡·áÁ¦°¡ Àüü ½ÃÀåÀÇ 13%¸¦ Â÷ÁöÇÏ°í ÀÖÀ» Á¤µµÀÌ´Ù. º» ¿¬±¸½Ç¿¡¼­´Â °¡Àå ÃÖ±Ù¿¡ ¹àÇôÁø ÀÌ¿ÂÅë·Î Áß ÇϳªÀÎ TRP ÀÌ¿ÂÅë·Î ¹× NALCN ÀÌ¿ÂÅë·Î µîÀÇ ¼¼Æ÷³» ±â´É°ú ±× Á¶Àý±âÀüÀ» ¿¬±¸ÇÏ°í ÀÖÀ¸¸ç, ÃÖ±Ù °ü·Ã³»¿ëÀ» 2020³â British Journal of Pharmacology, 2021³â eLife, 2023³â Journal of Physiology¿¡ ¹ßÇ¥ÇÏ¿´´Ù. ±Ã±ØÀûÀ¸·Î Èļӿ¬±¸¸¦ ÅëÇØ º» ÀÌ¿ÂÅë·Î °ü·Ã »ý¸®Çö»ó°ú ÁúȯÀÇ ¹ß»ý±âÀüÀ» ÀÌÇØÇÏ°í °ü·ÃÁúȯÀÇ Ä¡·á¹ý °³¹ß¿¡ ±â¿©ÇÏ°íÀÚ ÇÑ´Ù.

    2) ¿ÀÅäÆÄÁö(Autophagy) ¿¬±¸
    ¿ÀÅäÆÄÁö¶õ ¼¼Æ÷°¡ ½º½º·Î(Auto)¸¦ ¸Ô´Â(Phagy) ÀÚ°¡Æ÷½Ä ±â´ÉÀ¸·Î¼­, ¼¼Æ÷³» ºÒÇÊ¿äÇÑ ³»¿ë¹°À̳ª µ¶¼º ´Ü¹éÁú µîÀ» Á¦°ÅÇÏ°í À̸¦ ÀçÈ°¿ëÇÏ´Â ½Ã½ºÅÛÀÌ´Ù. ÀÌ·¯ÇÑ ¿ÀÅäÆÄÁö ±â´É¿¡ ¹®Á¦°¡ »ý±â¸é °¢Á¾ ¾Ï ¶Ç´Â Ä¡¸Å, ÆÄŲ½¼º´°ú °°Àº ½Å°æÅðÇ༺ ÁúȯÀÌ ¹ß»ýÇÏ°Ô µÈ´Ù. µû¶ó¼­ ¿ÀÅäÆÄÁö Á¶ÀýÀ» ÅëÇØ °ü·ÃÁúȯÀ» Ä¡·áÇÏ·Á´Â ½Ãµµ°¡ ÀÌ·ç¾îÁö°í ÀÖÀ¸³ª Ä¡·áŸ°ÙÀ» ã´Â µ¥¿¡ ¾î·Á¿òÀ» °Þ°í ÀÖ´Ù. º» ¿¬±¸½Ç¿¡¼­´Â ÀÌ¿ÂÅë·Î¸¦ ¿¬±¸ÇÏ´ø Áß ¼¼Æ÷³» Ä®½·Åë·ÎÀÎ TRPML3°¡ »õ·Î¿î ¿ÀÅäÆÄÁö Á¶ÀýÀÎÀÚÀÓÀ» ¹ß°ßÇÏ¿´´Ù. ÀÌ·¯ÇÑ ³»¿ëÀ» 2019³â Autophagy, 2022³â PNAS¿¡ ¹ßÇ¥ÇÏ¿´°í, ÇöÀç TRPML3 Á¦¾î¸¦ ÅëÇÑ ¿ÀÅäÆÄÁö ´Ü°èº° Á¶ÀýÀ» ¸ñÇ¥·Î ´Ù¾çÇÑ ¿ÀÅäÆÄÁö ¿¬±¸±â¹ýÀ» È°¿ëÇÏ¿© Èļӿ¬±¸¸¦ ÁøÇàÇÏ°í ÀÖ´Ù.

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  • 1. Proximal dendritic localization of NALCN channels underlies tonic and burst firing in nigral dopaminergic neurons. J Physiol. 2023 Jan601(1):171-193.
    2. The intracellular Ca2+ channel TRPML3 is a novel PI3P effector that regulates autophagosome biogenesis. PNAS 2022 Oct 25119(43)
    3. TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons. eLife. 2021 Aug 1910:e70920.
    4. N?benzhydryl quinuclidine compounds are a potent and Src kinase?independent inhibitor of NALCN channels. Br J Pharmacol. 2020 Aug177(16):3795-3810.
    5. Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy. Autophagy. 201915(2):327-340.