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  • ȨÆäÀÌÁö ¹Ù·Î°¡±â http://biomed.skku.edu/shum
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  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6123 / (fax)
  • À̸ÞÀÏ     £ü shum@skku.edu

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  • 1994 ¼º±Õ°ü´ëÇб³ ¾àÇаú, ¾àÇлç
    1996 ¼º±Õ°ü´ëÇб³ ¾àÇаú, ¾àÇм®»ç
    1996-1998 ¸ñ¾Ï »ý¸í°øÇÐ ¿¬±¸¼Ò ¿¬±¸¿ø
    1999-2004 ½ºÀ§½º Friedrich Miescher Institute for Biomedical Research,½ºÀ§½º University of Basel, Biochemistry, Ph.D.
    2004-2009 ¹Ì±¹ University of Cincinnati, College of Medicine, Postdoctoral Fellow
    2009-ÇöÀç ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ ±³¼ö

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  • ºñ¸¸°ú Á¦2Çü ´ç´¢º´, ½ÉÇ÷°ü°è Áúȯµî ´ë»ç¼º Áúȯµé¿¡¼­ ³ªÅ¸³ª´Â °øÅëµÈ Ư¡Àº nutrient homeostasisÀÇ ºÎÁ¶ÀýÀÌ´Ù. Nutrient homeostasis´Â À½½Ä¹° ¼·Ãë ÈÄ Ç÷´çÀÌ Áõ°¡µÉ ¶§, pancreatic beta cellÀÇ Àν¶¸° ºÐºñ, ±ÙÀ°¿¡¼­ÀÇ ´ç Èí¼ö, °£¿¡¼­ÀÇ gluconeogenesis ¾ïÁ¦, ³ú¿¡¼­ÀÇ ½Ä¿åÁ¶Àý°ú energy expenditure Á¶ÀýµîÀÌ ¿¬ÇÕÇÏ¿© ÀÌ·ç¾îÁø´Ù. Nutrient homeostasis À» À¯ÁöÇϴµ¥ Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â Á¶Á÷ ¼¼Æ÷³» ½ÅÈ£ Àü´Þ ü°è¿Í ´ë»çÁúȯ°úÀÇ ¿¬°ü¼º¿¡ ´ëÇØ ±¹³»¿Ü ¸¹Àº ¿¬±¸ÆÀµéÀÌ ¿¬±¸¸¦ ÁøÇàÇÏ°í ÀÖ´Ù.

    º» ¿¬±¸ÀÚ´Â Àν¶¸°°ú ¾Æ¹Ì³ë»ê µîÀÇ ¿µ¾çºÐÀÌ ¼¼Æ÷ ³»¿¡¼­ PI3K downstream °èÀÎ S6K1 signalingÀ» ÅëÇÑ ½ÅÈ£ Àü´Þ °úÁ¤À» ÀÌ¿ëÇÏ°í, ÀÌ ½ÅÈ£ Àü´Þ ü°èÀÇ ºÎÁ¶ÀýÀÌ ºñ¸¸°ú ¿¬°üµÈ »ýü³» Àν¶¸° ÀúÇ×¼º À¯µµ¿Í nutrient homeostasis ºÎÁ¶Àý¿¡ Á᫐ ¿ªÇÒÀ» ÇÑ´Ù´Â °ÍÀ» º¸°íÇÑ ¹Ù ÀÖ´Ù.

    º» ¿¬±¸½Ç¿¡¼­´Â knockout mouse¿Í knockdown ¹æ½ÄÀ» »ç¿ëÇÏ¿© ´ç ´ë»ç, ´ç ÇÕ¼º, ´ç Èí¼öµîÀÇ ´ë»ç Á¶Àý°úÁ¤¿¡¼­ ÇÙ½É ¿ªÇÒÀ» ÇÏ´Â nutrient sensing ±âÀÛ°ú ¿¬°üµÈ ½ÅÈ£Àü´Þü°è¿¡ ´ëÇÑ ¿¬±¸¸¦ ÁøÇàÇÏ°í ÀÖ´Ù. ÀÌ ¿¬±¸´Â ´ë»ç¼º ÁúȯÀÇ º´¸®¿¡ ´ëÇÑ ÀÌÇظ¦ ³ÐÈ÷°í µ¿½Ã¿¡ ´ë»ç¼º Áúȯ Ä¡·á¿¡ ÀÀ¿ëµÉ ¼ö ÀÖÀ» °ÍÀ̶ó »ç·áµÈ´Ù.

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  • 1) Kim HJ*, Lee DE*, Park EC, Ra M-J, Jung S-M, Yu J-M, Um SH**, and Kim KH**(* equally contributed) (**corresponding author),, 2022: Anti-Adipogenic Effects of Salicortin from the Twigs of Weeping Willow (Salix pseudolasiogyne) in 3T3-L1 Cells. Molecules, 27(20), 6954

    2) Kim HJ*, Jang YS*, Ha JW, Ra M-J, Jung S-M, Yu J-M, Kim K, Kim KH** and Um SH** (* equally contributed) (**corresponding author), 2022: Bioactive Phytochemicals from Salix pseudolasiogyne Twigs: Anti-Adipogenic Effect of 2''''-O-Acetylsalicortin in 3T3-L1 Cells.International Journal of Molecular Sciences,23(12006),1-11

    3) Im DU, Kim SC, Chau GC, Um SH*(*corresponding author), 2019: Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/¥â-Catenin Expression.Cells,8(11),1460-1474

    4) Son SW, Chau GC, Kim ST and Um SH*(*corresponding author), 2019: Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling. Cells, 8(10), 1137-1152

    5) Seo DS, Chau GC, Baek KH, Um SH*, 2019: A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis. Mol Metab., 21, 82-89

    6) Chau GC,* Im DU,* Kang TM, Bae JM, Won Kim, Pyo SN, Moon EY, and Um SH ** (*equally contribution), 2017: mTOR controls ChREBP transcriptional activity and pancreatic ¥â cell survival under diabetic stress. J. Cell Biol., 216(7), 2091-2105

    7) Um SH*, Sticker JM, Chau GC, Vintersten K, Mueller M, Gangliff YG, Adams RH, Spetz JF, Elghazi L, Tsch&246p MH, Thomas G and Kozma SC*. 2015: S6K1-mediated pancreatic b-cell size is independent of intrauterine growth restriction. J Clin Invest. 2015 Jul 1125(7):2736-47

    8) Kim KJ, Pyo S, Um SH*, 2012: S6K2 deficiency enhances ketone body production and increases PPAR¥á activity in the liver. Hepatology 2012 Jun 55(6):1727-37