±³½Ç¼Ò°³

    • home
    • ±³½Ç¼Ò°³
    • ±âÃÊÀÇÇÐ

±âÃÊÀÇÇÐ

  • ÀüÀÓ±³¼ö(ÀÇ°ú´ëÇÐ)
  • ½Åµ¿¿ì
  • ȨÆäÀÌÁö ¹Ù·Î°¡±â http://biomed.skku.edu/molbact
  • Àü°øºÐ¾ß £ü ÀÇÇм¼±ÕÇÐ
  • ¿¬¶ôó     £ü (ÀüÈ­) 031-299-6224 / (fax)
  • À̸ÞÀÏ     £ü shind@skku.edu

ÁÖ¿ä°æ·Â

  • 1996 ¼­¿ï´ëÇб³ ³ó¾÷»ý¸í°úÇдëÇÐ ½ÄÇ°°øÇаú Çлç
    1998 ¼­¿ï´ëÇб³ ³ó¾÷»ý¸í°úÇдëÇÐ Çùµ¿°úÁ¤ ³ó¾÷»ý¹°°øÇÐÀü°ø ¼®»ç
    2002 ¼­¿ï´ëÇб³ ³ó¾÷»ý¸í°úÇдëÇÐ ³ó»ý¸í°øÇкΠ¹Ú»ç (ºÐÀڹ̻ý¹°ÇÐ Àü°ø)
    2002 - 2003 Washington University, ºÐÀڹ̻ý¹°Çаú, Research Associate
    2003 - 2006 Howard Hughes Medical Institute, Washington University, ºÐÀڹ̻ý¹°Çаú, Research Associate
    2006 - 2007 ¼­¿ï´ëÇб³ ³ó¾÷»ý¹°½Å¼ÒÀ翬±¸¼Ò, ¿¬±¸Á¶±³¼ö
    2007 - ÇöÀç ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¶±³¼ö

ÁÖ¿ä°ü½É¿¬±¸

  • ±×¶÷À½¼º ¼¼±ÕÀÎ Salmonella´Â Àΰ£¿¡°Ô ¸Å³â ¼ö¹é¸¸ °ÇÀÇ Àå¿°°ú ÀåƼǪ½º¸¦ ÀÏÀ¸ÄÑ ¼öõ ¸íÀÇ »ç»óÀÚ¸¦ ³»´Â ¿øÀÎÀÌ´Ù. Salmonella´Â ÁÖ·Î ¿À¿°µÈ ¹°À̳ª ½ÄÇ°À» ÅëÇÏ¿© ü³»·Î µé¾î°¡ »ýÁ¸, Áõ½ÄÇÏ¿© Áúº´À» À¯¹ßÇϸç, ÀÌ´Â ÀÌ ¼¼±ÕÀÌ À§ÀÇ ±Ø»ê¼º ȯ°æ¿¡¼­ »ì¾Æ³²°í ¼ÒÀå¿¡ µµ´ÞÇÏ¿© »óÇǼ¼Æ÷ ³»·Î ħÅõ, ÀÌÈÄ ´ë½Ä¼¼Æ÷ ¾È¿¡¼­ Áõ½ÄÇÒ ¼ö ÀÖ´Â ´É·Â¿¡ ±âÀÎÇÑ´Ù. ÀÌ·¯ÇÑ »ç½ÇµéÀº Salmonella°¡ ÀûÀýÇÑ À¯ÀüÀÚµéÀÇ ¹ßÇö Á¶ÀýÀ» ÅëÇØ ´Ù¾çÇÑ È¯°æ¿¡ ÀûÀÀÇÏ´Â ¸ÞÄ¿´ÏÁòÀ» °®´Â ´Ù´Â °ÍÀ» ½Ã»çÇÑ´Ù.
    ÇöÀç ¿ì¸® ¿¬±¸½Ç¿¡¼­´Â ´Ù¾çÇÑ À¯ÀüÇÐÀû, ºÐÀÚ»ý¹°ÇÐÀû, »ýÈ­ÇÐÀû ½ÇÇè¹æ¹ýµéÀ» ÀÌ¿ëÇÏ¿© SalmonellaÀÇ ¼÷ÁÖ¼¼Æ÷ ¾È¿¡¼­ÀÇ »ýÁ¸¿¡ ÇÊ¿äÇÑ »õ·Î¿î º´¿ø¼º ÀÎÀÚ¸¦ ã¾Æ ±× ±â´ÉÀ» ±Ô¸íÇÏ°í, ´Ù¾çÇÑ º´¿ø¼º À¯ÀüÀÚµéÀÇ ¹ßÇöÀ» À¯±âÀûÀ¸·Î Á¶ÀýÇÏ´Â two-component signal transduction systemÀÇ ¿ªÇÒÀ» ÀÌÇØÇϴµ¥ ÃÊÁ¡À» ¸ÂÃç ¿¬±¸ÇÏ°í ÀÖ´Ù. ÀÌ·¯ÇÑ ¿¬±¸¿¡¼­ ¾ò¾îÁö´Â °á°úµéÀº ¼¼±ÕÀÌ ¾î¶»°Ô ´Ù¾çÇÑ È¯°æ ½ÅÈ£ÀÎÀÚµéÀ» ó¸®ÇÏ¿© ±× ¼¼Æ÷ÀÇ ÀûÀýÇÑ ÀûÀÀÀ» À̲ø¾î ³¾ ¼ö Àִ°¡¶ó´Â ±âÃÊÀû Ãø¸é »Ó ¾Æ´Ï¶ó, ¼¼±ÕÀÇ º´¿ø¼ºÀ» Á¦¾îÇÒ ¼ö ÀÖ´Â »õ·Î¿î ÇØ°áÃ¥À» Á¦½ÃÇÒ ¼ö ÀÖÀ» °ÍÀÌ´Ù.

´ëÇ¥¿¬±¸¾÷Àû

  • 1) Perez JC, Shin D, Zwir I, Latifi T, Hadley TJ, Groisman EA. (2009) Evolution of a bacterial regulon controlling virulence and Mg(2+) homeostasis. PLoS Genet. 5: e1000428.

    2) Jeon, J., Kim, H., Yun, J., Ryu, S., Groisman, E. A. and Shin, D. (2008) The RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica. J. Bacteriol. 190: 7326-7334.

    3) Shin, D., Lee, E. J., Huang, H., and Groisman, E. A. (2006) A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science 314: 1607-1609.

    4) Zwir, I., Shin, D., Kato, A., Nishino, K., Latifi, T., Solomon, F., Hare, J. M., Huang, H., and Groisman, E. A. (2005) Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proc. Natl. Acad. Sci. USA. 102: 2862-2867.

    5) Shin, D. and Groisman, E. A. (2005) Signal-dependent binding of the response regulators PhoP and PmrA to their target promoters in vivo. J. Biol. Chem. 280: 4089-4094.

    6) Shin, D., Cho, N., Heu, S., and Ryu, S. (2003) Selective regulation of ptsG expression by Fis: formation of either activating or repressing nucleoprotein complex in response to glucose. J. Biol. Chem. 278: 14776-14781.

    7) Nam, T. W*., Cho, S. H*., Shin, D.*, Kim, J. H., Jeong, J. Y., Lee, J. H., Roe, J. H., Peterkofsky, A., Kang, S. O., Ryu, S., and Seok, Y. J. (2001) The Escherichia coli glucose transporter enzyme IICBGlc recruits the global repressor Mlc. EMBO J. 20: 491-498. (*co-first authors)