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Title Professor Ilmin Kwon published Article in international journal Cell
Name SKKUSOM Date  2016-10-27 Hit 989

SKKU-SOM Professor Ilmin Kwon published Article in international journal Cell

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers

 

Prof. Ilmin Kwon of the Department of Anatomy and Cell Biology Sungkyunkwan University School of Medicine and Steven L. McKnight of the Department of Biochemistry UT Southwestern Medical Center and their team used two complementary approaches in search of intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of amyotrophic lateral sclerosis (ALS).

ALS, also known as Lou Gehrig¡¯s disease that cause the extinction of motor neuron of the central nervous system of the patients is the reason of stiffen and shrunken muscle and finally patients die because of stiffen respiration muscle. According to several recent studies, about half of ALS is derived from C9orf72 mutation.

Evidence is presented indicating that low complexity (LC) sequences represent the direct target of PR £î binding and that interaction between the PR £î poly-dipeptide and LC domains is polymer-dependent. These studies indicate that PR £î –mediated toxicity may result from broad impediments to the dynamics of cell structure and information flow from gene to message to protein.

Prof. Ilmin Kwon¡¯s article was published on October 21st in the renowned international journal Cell .

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