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기초의학

    주요경력

    • 2012-present Sungkyunkwan University School of Medicine (Professor)
      2010-present Samsung Advanced Institute for Health Sciences and Technology (Professor)
      2006-2012 Sungkyunkwan University School of Medicine (Associate Professor)
      2002-2006 National Cancer Center (Senior Research Associate)
      1998-2000 Harvard Medical School (Post-doctoral fellow)
      1994-1998 University of Glasgow (UK) / National Institute for Medical Research (Ph.D.)

    주요관심연구

    • 1. 종양면역(tumor immunity), 면역체크포인트(immune checkpoint) 및 자가면역(autoimmunity)의 새로운 조절 기전 및 병인 기전 연구
      : 종양면역에서 핵심적인 T 세포의 exhaustion 및 anergy 을 조절하는 새로운 분자기전을 연구팀에서 독자적으로 구축한 다양한 conditional knock-out (KO) 및 transgenic (Tg) 마우스를 활용하여 종양면역의 새로운 분자기전을 제시하고 진단 및 치료기술을 개발하고자 함.

      2. 저분자화합물 및 항체를 이용한 혈액암, 림프종 및 자가면역질환의 치료기술 개발
      : 본 연구팀에서 새롭게 발굴한 저분자화합물과 항체를 연구팀에서 구축한 다양한 종양 마우스 모델과 자가면역질환 마우스 모델에서 후보 치료물질에 의한 치료 효능의 검증, 작용 기전 및 독성 분석을 수행함.

      3. 연구실에서 발굴한 Ssu72 (dual protein phosphatase)와 새로운 타입의 Pellino1 (ubiquitin E3 ligase)에 의한 질병의 새로운 발병 기전 및 치료의 분자표적에 대한 연구를 수행함
      : 본 연구팀에서 구축한 다양한 종류의 conventional Tg, inducible Tg, conditional Tg mice 그리고 KO과 conditional KO mice을 이용하여 Ssu72와 Pellino 1 각각의 gain-of-function과 loss-of-function에 의한 질병화의 새로운 분자기전 및 치료기술에 대해서 연구함. 연구팀에서는 15종류 이상의 마우스를 활용하여 다양한 종류의 T 세포(CD4+, CD8+, Treg 및 Th17 cells), B 세포, microphage, adipocyte, hepatocyte, stem cell, keratinocyte, oval cell 등의 새로운 세포기능 및 관련된 질병에 대해서 연구함.

    대표연구업적

    • Kim HS*, Yoon JS*, Jeon Y, Park EJ, Lee JK, Lee H, Park JY, Go H, and Lee CW. 2021. Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma. Cell Death and Differentiation (in press). (IF 15.881) *denotes co-first authors

      Ko JS, Jeong D, Koh J, Jung H, Jung KC, Jeon YK, Kim HY, Yi EC, Lee H, Lee CW#, and Chung DH#. 2021. Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation. Proc Natl Acad Sci U S A. 118(35):e2102374118. (IF 11.205) #denotes co-corresponding authors

      Lee JK*, Koo SY*, Nam HM, Lee JB, Ko J, Kim KM, Park EJ, Kim TJ, Lee H, Go H and Lee CW. 2021. Ssu72 isa T cell receptor-responsive modifier which is indispensable for regulatory T cells. Cellular and Molecular Immunology 18:1395-1411. (IF 11.530) *denotes co-first authors

      Ha GH, Ji JH, Chae S, Park J, Kim S, Lee JK, Park JM, Kang TH, Lee H, Cho H, and Lee CW. 2019. Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks. Nature Communications 10:1577: 1-18. (IF 14.919)

      Ji JH, Min S, Chae S, Kim Y, Park YJi, Lee CW, and Cho H. 2019. De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair. Nucleic Acids Research 9:47 6299-6314. (IF 16.971)

      Choi SW, Park HH, Kim S, Chung JM, Noh HJ, Kim SK, Song HK, Lee CW, Morgan MJ, Kang HC, Kim YS. 2018. Peli1 ively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. Molecular Cell 7:70 920-935. (IF 17.970)

      Lee HS, Lin Z, Chae S, Yoo YS, Lee Y, Johnson JL, Cantely LC, Kim YS, Lee CW, Yu H, and Cho H. 2018. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications 9:3848 1-13. (IF 14.919)

      Jeon YK, Kim CK, Hwang KR, Park HY, Koh J, Chung DH, Lee CW, and Ha GH. 2017. Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination. Cell Death Differentiation 24:3 469-480. (IF 15.881)

      Kim SH, Jeon Y, Kim HS, Lee JK, Lim HJ, Kang DR, Cho HS, Park CK, Lee H, and Lee CW. 2016. Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology 63:247-259. (IF 17.425)

      Lee HS, Park YY, Cho MY, Chae SY, You YS, Kwon MH, Lee CW, and Cho HS. 2015. The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores. Nature Communications 6:7904 1-14. (IF 14.919)

      Park HY, Go HJ, Song HR, Kim SH, Ha GH, Jeon YK, Kim JE, Lee Ho, Cho HS, Kang HC, Chung HY, Kim CW, Chung DH, and Lee CW. 2014. Pellino1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. Journal of Clinical Investigation 124:4976-4988. (IF 14.808)

      Kim TJ, Jin HT, Hur SY, Yang HG, Seo YB, Hong SR, Lee CW, Kim SH, Woo JW, Park KS, Hwang YY, Park JH, Lee IH, Lim KT, Lee KH, Jeong MS, Seo C.D., Suh YS, Park JS, and Sung YC. 2014. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 pateints. Nature Communications 5:5317 1-14. (IF 14.919)

      Kim JH, Shim JG, Ji MJ, Jung YN, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee CW, Lee BI, Kim KT. 2014. The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores. Nature Communications 4588:5 1-13. (IF 14.919)

      Kim HS, Kim SH, Park HY, Lee J, Yoon JH, Choi SK, Ryu SH, Lee H, Cho HS, and Lee CW. 2013. Functional interplay between Aurora B Kinase and Ssu72 phosphatase in regulating sister chromatid cohesion during early mitosis. Nature Communications 4:1-14. (IF 14.919)

      Yang KM, Park GY, Han YK, Lee JH, Chun SH, Park HY, Lim KH, Kim EG, Choi YJ, Lee CG, and Lee CW. 2013. Roles of 14-3-3 eta in mitotic progression and its possibility as a therapeutic target for cancers. Oncogene 32:1560-1596. (IF 9.867)

      Ha GH, Kim HS, Go H, Lee H, Seimiya H, Chung DH, and Lee CW. 2012. TNKS 1 function at telomere and during mitosis is regulated by Polo-like kinase 1-mediated phosphorylation. Cell Death and Differentiation 19:321-332. (IF 15.881)

      Kim HS, Baek KH, Ha GH, Lee JC, Kim YN, Lee J, Park HY, Lee NR, Lee Ho, Cho Y, and Lee CW. 2010. The hsSsu72 phosphatase is a cohesion-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO Journal 29:3544-57. (IF 11.598)

      Kim HS, Jeon YK, Ha GH, Park HY, Kim YJ, Shin HJ, Lee CG, Chung DH, and Lee CW. 2009. Functional interaction between BubR1 and securin in an APCCdc20-independent manner. Cancer Research 69:27-36. (IF 12.701)

      Ha GH, Kim HS, Lee CG, Park HY, Kim EJ, Shin HJ, Lee JC, Lee KW, and Lee CW. 2009. Mitotic Catastrophe is the Predominant Response to Histone Acetyltransferase Depletion. Cell Death and Differentiation 16:483-497. (IF 15.881)

      Kim HS, Jeon YK, Ha GH, Park HY, Kim YJ, Shin HJ, Lee CG, Chung DH, and Lee CW. 2008. Functional Interaction Between BubR1 and Securin in an APCCdc20-independent manner. Cancer Research 69:27-36. (IF 12.701)

      Ha GH, Baek KH, Jeong SJ, Kim HS, Kim CM, McKeon F, and Lee CW. 2007. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Research 67:7155-7164. (IF 12.701)

      Shin HJ, Park HY, Jeong SJ, Kim YG, Cho SH, Kim YY, Cho ML, Kim HY, Min KU, and Lee CW. 2005. STAT4 e-pression in human T cells is regulated by DNA methylation but not by promoter polymorphism. Journal of Immunology 175:7143-7150.

      Jeong SJ, Shin HJ, Kim SJ, Ha GH, Baek KH, Kim CM, and Lee CW. 2004. Transcriptional abnormality of hsMAD2 mitotic checkpoint gene is a potential link to hepatocellular carcinogenesis. Cancer Research 64:8666-8673. (IF 12.701)

      Shin HJ*, Baek KH*, Jeon AH, Chung DH, Lee SJ, Lee HS, Sung YC, McKeon F, and Lee CW. 2004. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 4:483-497. (IF 31.743)

      Shin HJ, Baek KH, Jeon AH, Kim SJ, Jang KL, Sung YC, and Lee CW. 2003. Inhibition of histone deacetylase activity increases the chromosomal instability by the aberrant regulation of mitotic checkpoint activation. Oncogene 22:3853-3858. (SCI IF 9.867)