Kim, Kyeong Kyu, Professor

Contact
  Tel: +82-31-299-6136
  Fax: +82-31-299-6159
  e-mail: kyeongkyu@skku.eu
  Lab homepage: http://smsb1.skku.ac.kr
Background:

2000 - Present:   Assistant/Associate/full Professor, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Korea
2006 - present:   Professor, Sungkyunkwan Advanced Institute of Nanotechnology
2010 - present:    Professor, Samsung Advanced Institute for Health Science & Technology
1998 - 2000:   Assistant Professor, Gyeongsang National University, Korea
     
1994 - 1998:   Post-doctoral fellow, Department of Chemistry, University of California, USA

1994:

  Ph.D. Department of Chemistry (Biochemistry), Seoul National University, Korea

1991:

  M. S. Department of Chemistry (Biochemistry), Seoul National University, Korea

1989:

  B. S. Department of Chemistry, Seoul National University, Korea


Research:
Prof. Kyeong Kyu Kim has been working on diverse areas in biomedical sciences including cancer, infectious diseases and regenerative medicine, by applying structural and chemical biology tools throughout. His ongoing research projects focus on various macromolecules involved in protein metabolism, stem cell differentiation, microbial pathogenesis and non-canonical DNA, such as Z-DNA, G-quadreplex and triplex in genome. Furthermore, his research encompasses nanobiotechnology in which biomacormolecules are combined with inorganic nanostructures to produce novel functional molecules for biomedical and material applications. These issues have been received extensive attention as the major questions of current biomedical sciences. We aim to apply our understanding on these systems to the development of novel therapeutics.

Publications (selected, *correspondence):
1. Ubiquitin specific protease 4 positively regulates the WNT/-catenin signaling in colorectal cancer. Yun
    SI, Kim HH, Yoon JH, Park WS, Hahn MJ, Kim HC, Chung CH, Kim KK*. Mol Oncol. 2015 Jul 3. pii: S1574-
    7891(15)00137-4.
2. Distinct rayleigh scattering from hot spot mutant p53 proteins reveals cancer cells. Jun HJ, Nguyen AH,
    Kim YH, Park KH, Kim D, Kim KK*, Sim SJ*. Small. 2014 Jul;10 (14):2954-62.
3. Single molecule visualization and characterization of Sox2-Pax6 complex formation on a regulatory DNA
    element using a DNA origami frame. Yamamoto S, De D, Hidaka K, Kim KK*, Endo M*, Sugiyama H*.
    Nano Lett. 2014 May 14;14(5):2286-92. doi: 10.1021/nl4044949. Epub 2014 Apr 4.
4. Distinct Z-DNA binding mode of a PKR-like protein kinase containing a Z-DNA binding domain (PKZ). Kim
    D, Hur J, Park K, Bae S, Shin D, Ha SC, Hwang HY, Hohng S, Lee JH, Lee S, Kim YG, Kim KK*. Nucleic Acids
    Res. 2014 May 1;42(9):5937-48. doi: 10.1093/nar/gku189. Epub 2014 Mar 20.
5. Inhibition of master transcription factors in pluripotent cells induces early stage differentiation. De D,
    Jeong MH, Leem YE, Svergun DI, Wemmer DE, Kang JS*, Kim KK*, Kim SH*. Proc Natl Acad Sci U S A.
    2014 Feb 14; 111(5): 1778-83.
6. Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor. Le VB, Kim H, Choi JK,
    Kim JH, Hahn MJ, Lee C, Kim KK*, Hwang HY*. Journal of Molecular Biology 2011 Nov 25;414(2):231-42
7. Platinum nanoparticles encapsulated by aminopeptidase: a multifunctional bioinorganic nanohybrid
    catalyst. San BH, Kim S, Moh SH, Lee H, Jung DY, Kim KK*. Angew Chem Int Ed Engl. 2011 Dec
    9;50(50):11924-9
8. Solution structure of the Z domain of human DAI and its binding modes to B- and Z-DNAs. Kim K,
    Khayrutdinov BI, Lee CK, Cheong HK, Kang SW, Park H, Lee H, Kim YG, Rich A, Kim KK*, Jeon YH*. Proc
    Natl Acad Sci U S A. 2011 Apr 26;108(17):6921-6.
9. Intrinsic Z-DNA Is Stabilized by the Conformational Selection Mechanism of Z-DNA-Binding Proteins. Bae
    S, Kim D, Kim KK*, Kim YG*, Hohng S*. J Am Chem Soc. 2011 Feb 2;133(4):668-71.
10. Structure-based development of a receptor activator of nuclear factor-B ligand (RANKL)RANKL
    inhibitor peptide and molecular basis for osteopetrosis. Ta HM, Nguyen GT, Jin HM, Choi J, Park H, Kim
    N, Hwang HY, Kim KK*. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20281-6.